A specific antibody response to HCV E2 elicited in mice by intramuscular inoculation of plasmid DNA containing coding sequences for E2
نویسندگان
چکیده
منابع مشابه
Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer.
We describe an improved genetic immunization strategy for eliciting a full spectrum of anti-hepatitis C virus (HCV) envelope 2 (E2) glycoprotein responses in mammals through electrical gene transfer (EGT) of plasmid DNA into muscle fibers. Intramuscular injection of a plasmid encoding a cross-reactive hypervariable region 1 (HVR1) peptide mimic fused at the N terminus of the E2 ectodomain, foll...
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متن کاملطراحی و ساخت سازه ی E2-fliC با استفاده از ژن fliC باکتری سالمونلا انتریکا و ژن E2 ویروس هپاتیت C و بیان آن در سیستم یوکاریوتی
Background and Aim: At the present time one of the strategies in vaccine design is generation of fusion proteins containing (including) immunogen of infectious agents and adjuvants. In this study design and construction of E2-fliC fragment as a vaccine candid was conducted by using fliC gene from Salmonella enterica and E2 gene from hepatitis C virus. Materials and Methods: To prepare the E2-f...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1997
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510250234